职称 教授
学位 博士
政治面貌 群众
邮箱 sujianguo@mail.hzau.edu.cn
研究方向 水产动物免疫学、水产动物病害防控
教育经历
2002年9月至2005年7月在中国科学院海洋研究所学习，获博士学位；
1998年9月至2001年12月在西北农林科技大学动物科技学院学习，获硕士学位；
1991年9月至1995年7月在上海水产大学渔业学院学习，获学士学位。
主要职历
1995.07 - 2000.11：助教，西北农林科技大学动物科技学院
2000.11 - 2005.12：讲师，西北农林科技大学动物科技学院
2003.06 - 2004.06：访问学者（国家留学基金委资助），澳大利亚联邦科学与工业联合组织（CSIRO）
2005.12 - 2009.12：副教授，西北农林科技大学动物科技学院
2006.04 - 2008.03：博士后，中国科学院水生生物研究所
2009.12 - 2014.08：教授，西北农林科技大学动物科技学院
2014.09 - 至今：教授，皇冠Welcome最新版本下载
科研成果
研究方向、项目及学术兼职
主要从事鱼类抗病毒抗细菌免疫机制、抗病育种、纳米肽、免疫增强剂、疫苗及佐剂研究，提高养殖鱼类的免疫力和抗病性状，积极主动的应对疾病的发生。先后承担了“十二五”国家科技支撑计划子课题、“十三五”国家重点研发计划子课题、“十四五”国家重点研发子课题、科技创新2030重大项目子任务、国家自然科学基金6项、湖北省重大科技创新计划项目等科研项目。教育部新世纪优秀人才、湖北省楚天学者特聘教授、Asia Society of Developmental and Comparative Immunology理事、中国水产学会水产动物免疫学专业委员会委员、中国水产学会鱼病专业委员会委员、青岛海洋科技中心PI、湖北洪山实验室PI、Developmental and Comparative Immunology、Comparative Immunology reports等编委。发表论文200余篇，引用次数5100余次，H指数40。2021全球兽医学高产作者Top100。2023、2024年度全球前2%顶尖科学家。爱思唯尔2020、2021、2022、2023中国高被引学者。
代表性论著：
1. Jianguo Su*. Toll-like receptor signaling in teleosts. Science China Life Sciences, 2024; (accept)
2. Zhiwei Liao, Chunrong Yang, Rui Jiang, Wentao Zhu, Yongan Zhang, Jianguo Su*. Cyprinid-specific duplicated membrane TLR5 senses dsRNA as functional homodimeric receptors. EMBO Reports, 2022; 23(8):e54281.
3. Yanqi Zhang, Ning Xia, Yazhen Hu, Wentao Zhu, Chunrong Yang, Jianguo Su*. Bactericidal ability of target acidic phospholipids and phagocytosis of CDC42 GTPase-mediated cytoskeletal rearrangement define functional conservation of CXCL12 in vertebrates. Science China Life Sciences 2024; 67(12):2713-2729.
4. Ning Xia, Yanqi Zhang, Wentao Zhu, Jianguo Su*. GCRV-II invades monocytes/macrophages and induces macrophages polarization and apoptosis in tissues to facilitate viral replication and dissemination. Journal of Virology 2024; 98(3): e01469-23 (Editor’s pick).
5. Zhiwei Liao#, Wei Ji#, Chunrong Yang, Jianguo Su*. TLR5M and TLR5S synergistically sense flagellin in early endosome in lamprey Petromyzon marinus, switched by the N-glycosylation site N239. The Journal of Immunology 2024; 212(5):855-867.
6. Bo Liang, Wenqian Li, Chunrong Yang, Jianguo Su*. LGP2 facilitates bacterial escape through binding peptidoglycan via EEK motif and suppressing NOD2-RIP2 axis in Cyprinidae and Xenocyprididae families. The Journal of Immunology 2024; 212(11):1791-1806.
7. Wentao Zhu, Yanqi Zhang, Zhiwei Liao, Xingchen Huo, Chunrong Yang, Yongan Zhang, Jianguo Su*. IFN1 enhances thrombocyte phagocytosis through IFN receptor complex-JAK/STAT-complement C3.3-CR1 pathway and facilitates antibacterial immune regulation in teleost. The Journal of Immunology 2023; 210(8):1043-1058.
8. Yanqi Zhang, Xun Xiao, Yazhen Hu, Zhiwei Liao, Wentao Zhu, Rui Jiang, Chunrong Yang, Yongan Zhang, Jianguo Su*. CXCL20a, a teleost-specific chemokine, which orchestrates direct bactericidal, chemotactic and phagocytosis-killing-promoting functions, contributes to clearance of bacterial infections. The Journal of Immunology 2021; 207(7):1911-1925.
9. Xun Xiao, Wentao Zhu, Yanqi Zhang, Zhiwei Liao, Changsong Wu, Chunrong Yang, Yongan Zhang, Shaobo Xiao, Jianguo Su*. Broad-spectrum robust direct bactericidal activity of fish IFNφ1 reveals an antimicrobial peptide-like function for type I IFNs in vertebrates. The Journal of Immunology 2021; 206(6):1337-1347.
10. Chengjian Fan, Hang Su, Zhiwei Liao, Juanjuan Su, Chunrong Yang, Yongan Zhang, Jianguo Su*. Teleost-specific MxG, a traitor in the Mx family, negatively regulates antiviral responses by targeting IPS-1 for proteasomal degradation and STING for lysosomal degradation. The Journal of Immunology 2021; 207(1):281-295.
11. Jianfei Ji, Youliang Rao, Quyuan Wan, Zhiwei Liao, Jianguo Su*. Teleost-specific TLR19 Localizes to Endosome, Recognizes dsRNA, Recruits TRIF, Triggers both IFN and NF-κB Pathways and Protects Cells from Grass Carp Reovirus Infection. The Journal of Immunology 2018; 200(2):573-585.
12. Youliang Rao, Quanyuan Wan, Hang Su, Xun Xiao, Zhiwei Liao, Jianfei Ji, Chunrong Yang, Li Lin, Jianguo Su*. ROS-induced HSP70 promotes cytoplasmic translocation of high-mobility group box 1b and stimulates antiviral autophagy in grass carp kidney cells. The Journal of Biological Chemistry 2018; 293(45):17387-17401.
13. Youliang Rao, Jianguo Su*, Chunrong Yang, Nana Yan, Xiaohui Chen, Xiaoli Feng. Dynamic localization and the associated translocation mechanism of HMGBs in response to GCRV challenge in CIK cells. Cellular & Molecular Immunology 2015; 12(3): 342-353.
14. Xingchen Huo, Fengxia Zhao, Yuezong Xu, Qian Liu, Weicheng Wang, Chunrong Yang, Jianguo Su*. Fabulous combination therapy: synergistic antibiotic inhibition of aquatic antibiotic-resistant bacteria via membrane damage and DNA binding by novel nano antimicrobial peptide C-I20. Journal of Hazardous Materials, 2024; 480:136225.
15. Wentao Zhu, Jianguo Su*. Immune functions of phagocytic blood cells in teleost. Reviews in Aquaculture 2022; 14:630-646.
16. Jianguo Su*. The discovery of type IV interferon system revolutionizes interferon family and opens up a new frontier in jawed vertebrate immune defense. SCIENCE CHINA Life Sciences 2022; 65(11):2335-2337.
17. 苏建国主编. 《水产动物免疫学》. 2020年5月；北京：中国农业出版社. ISBN:978-7-109-26024-5.（副主编：袁改玲、宋林生、秦启伟；参编：徐镇、刘学芹、邹钧、邢婧、刘海鹏、李成华、王高学、姚翠鸾、鲁义善、姜有声）；普通高等教育农业农村部“十三五”规划教材；全国高等农林院校“十三五”规划教材；农业农村部“十四五”规划教材；全国农业教育优秀教材。
授权专利：
1. 发明专利. Jianguo Su, Xun Xiao, Wentao Zhu. Polypeptide derivatives from grass carp interferon and application hereof US 10,577,404 B2.
2. 发明专利. 苏建国,张艳七,王振生. 分离自草鱼的CXCL20a蛋白在作为抗菌肽中的应用 202110684138.8.
3. 发明专利. 苏建国,廖志伟,万全元,尚雪莹. 一种草鱼出血病免疫性状相关的遗传标记 201610701194.7.
4. 发明专利. 苏建国,苏航,袁改玲. 一种对草鱼有免疫增强活性的CpGODN序列及其应用 201510826879X.
5. 发明专利. 苏建国，肖循，朱文涛. 一种来源于草鱼干扰素的衍生多肽及其应用 201810503117X.
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